LGR5 - leucine rich repeat containing G protein-coupled receptor 5 Gene

Also Known as FEX; HG38; GPR49; GPR67; GRP49

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8549

About LGR5

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,439,129-71,586,310 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 22 paralogues. Biased expression in placenta (RPKM 11.9), small intestine (RPKM 3.2) and 8 other tissues.

Summary

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

LGR5 Products (3)

mRNA	Protein	Name
NM_001277226.2	NP_001264155.1	leucine-rich repeat-containing G-protein coupled receptor 5 isoform 2 precursor
NM_001277227.2	NP_001264156.1	leucine-rich repeat-containing G-protein coupled receptor 5 isoform 3 precursor
NM_003667.4	NP_003658.1	leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	21693646	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21693646	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	21693646	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	21693646	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21693646	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	23439653	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGR5 Protein Structure

LRRNT

LRR_8

LRR_5

LRR_1

LRR_8

7tm_1

0
200
400
600
800
907 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat-containing G-protein coupled receptor 5	G-protein coupled receptor 49

LGR5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LGR5	O75473	RSPO1	Homo sapiens	Q2MKA7	GMS	23809763
Intra	LGR5	O75473	RSPO1	Homo sapiens	Q2MKA7	Anti Tag CoIP	23809763
Intra	LGR5	O75473	RSPO1	Homo sapiens	Q2MKA7	X-Ray Diffraction	23809763

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LGR5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79308	Lgr5/GPR49 Protein, Human (CHO, hFc)	O75473-1 (G22-I560)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700891	Lgr5/GPR49 Protein, Human (HEK293, hFc)	O75473-1 (G22-P543)	≥ 90%, as determined by reducing SDS-PAGE.

LGR5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82097	LGR5 Antibody (YA1842)	WB, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ankyloglossia With Or Without Tooth Anomalies	Ankyloglossia ANKG 'Tongue-Tie' Tongue-Tie Tongue Tie Aberrant Insertion Of Labial Frenulum Aberrant Insertion Of Frenum Of Tongue Short Frenulum Linguae Short Frenulum Of Tongue
Mucositis	Inflammatory Disease Of Mucous Membrane Gastrointestinal Mucositis
Mesenteric Vascular Occlusion
Colon Adenoma	Adenomatous Polyp Of Colon
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Intestinal Benign Neoplasm	Intestinal Neoplasms Intestinal Tumors Intestine Growth Neoplasm Of Intestinal Tract
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Non-Syndromic X-Linked Intellectual Disability 107	Mrx107 X-Linked Mental Retardation 107
Chemical Colitis
Lymphangioma	Lymphatic Malformation Lymphatic Malformations Benign Lymphangioma Congenital Lymphangioma Lymphangiomas
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome	ACOGS
Gastrointestinal System Benign Neoplasm
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec
Corneal Dystrophy, Posterior Polymorphous, 4	PPCD4 Posterior Polymorphous Corneal Dystrophy 4
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Immunodeficiency 58	IMD58 Severe Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Rltpr Deficiency
Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis	ECTD14 Ectodermal Dysplasia 14 Ectn14
Deafness, Autosomal Recessive 98	DFNB98 Autosomal Recessive Nonsyndromic Deafness 98 Autosomal Recessive Deafness 98 Deafness, Autosomal Recessive, 98 Deafness, Autosomal Recessive, Type 98
Retinitis Pigmentosa 11	RP11 Retinitis Pigmentosa-11 Retinitis Pigmentosa, Type 11
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99406	Petosemtamab	Degrader	99.94%	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10810	QPH-FR	Inhibitor	99.54%	Unkown
HY-RS07619	LGR5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20763	Lgr5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27277	Lgr5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99406A	Petosemtamab (FUT8-KO)	Degrader	99%	Unkown
HY-P991454	Anti-LGR5/GPR49 Antibody (18G7H6A3)	Inhibitor	98.64%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LGR5	MGD	MGI:1341817
Macaca mulatta	LGR5	VGNC	VGNC:74181
Felis catus	LGR5	VGNC	VGNC:67431
Bos taurus	LGR5	VGNC	VGNC:30862
Rattus norvegicus	LGR5	RGD	RGD:1307733
Others	LGR5	NCBI